Type 1 juvenile diabetes Some suggest that vitamin D3 may be an important pathogenic factor in type 1 diabetes independent of geographical latitude [7]. Diabetes mellitus type 2 is a chronic, progressive disease that cannot now be cured. Type 2 may go unnoticed for years in a patient before diagnosis, since the symptoms are typically milder (no ketoacidosis) and can be sporadic. The onset of the disease is most mon in middle age and later life. In addition, a small proportion of Type 1 cases have the hereditary condition maturity onset diabetes of the young (MODY) which can also be confused with Type 2. However, severe plications can result from unnoticed type 2 diabetes, including renal failure, blindness, wounds that fail to heal, and coronary artery disease. The greatest increase in prevalence is, however, expected to occur in Asia and Africa, where most patients will likely be found by 2030. A subtype of type 1 (identifiable by the presence of antibodies against beta cells) typically develops slowly and so is often confused with Type 2. The liver is expected to be the most reasonable choice because it is more accessible than the pancreas and the Islet cells seem to produce insulin well in that environment. About 90-95% of all North American cases of diabetes are type 2, and about 20% of the population over the age of 65 has diabetes mellitus type 2. The most useful laboratory test to distinguish Type 1 from Type 2 diabetes is the C-peptide assay, which is a measure of endogenous insulin production since external insulin to date has included no C-peptide. The American Diabetes Association funds some work on Type I, but also devotes much of its resources to Type II Diabetes. Type 2 may go unnoticed for years in a patient before diagnosis, since the symptoms are typically milder (no ketoacidosis) and can be sporadic. Type 2 may go unnoticed for years in a patient before diagnosis, since the symptoms are typically milder (no ketoacidosis) and can be sporadic. Type 1 juvenile diabetes. Total body irradiation (TBI) is also associated with a higher risk of developing diabetes. |